Science behind metis Anti-Stress 03

The science behind metis Anti-Stress 03


We strongly question current supplements. Skeptical we certainly are. A high concentration to stress less? Check. Each formula has been perfected for maximum effect from the various ingredients. Thus, each capsule contains a decisive dose of natural, active substances.

metis Anti-Stress 03 helps the body better cope with stress. It tempers the stress response and reduces the impact of stress on you and your mood. This by using only the highest quality and proven ingredients. Less stress? Be yourself again!

Sugar free
No artificial colors
No synthetic preservatives
No artificial flavors or fragrances
Not addictive

Ashwagandha KSM 66, Holy basil extract and Lemon balm

  • Ashwagandha KSM 66 is an adaptogen of absolute world class. This adaptogen supports the body in the face of stress. It not only improves energy levels but creates a balanced state of mind. Anxiety and stress are remarkably reduced. Moreover, this is one of the most scientifically researched, ecological and highly concentrated ashwagandha extract available.
  • Holy basil extract is not your everyday basil. Also has adaptogenic properties but more with a focus on improving melancholy and depressive symptoms. So it has a positive effect on mood. Cognitive performance is also positively affected. Ideal for work related stress or exams.
  • Lemon balm improves anxiety and sleep problems.

Lactobacillus subtilis HU58 & Coagulans

  • These spore-forming probiotics, and in particular Lactobacillus subtilis HU58, of human origin are fully absorbed and play a very important role in intestinal balance and immunity.
  • The intestines and digestion have an enormous influence on mood and general well-being.
  • The psychobiotics start to support the gut-brain relationship. There one sees a marked decrease in panic and anxiety attacks. It also reduces continued brooding.


K. Chandrasekhar, Jyoti Kapoor, and Sridhar Anishetty: A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy ofa High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. Indian J Psychol Med. 2012 Jul-Sep;

34(3): 255–262.

Shin Jie, Yong & Tong, Tommy & Chew, Jactty & Lim, Wei. (2020). Antidepressant Mechanisms of Probiotics and Their Therapeutic Potential. Frontiers in Neuroscience. 13. 1361. 10.3389/fnins.2019.01361.

Huang R, Wang K, Hu J. Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2016 Aug 6;8(8):483. doi: 10.3390/nu8080483. PMID: 27509521; PMCID: PMC4997396.

"More in a capsule. More out of life."

Are you willing to give it your all? Then you'll get more from us. Because in your hectic life, sometimes the bar is set high. How do you stay on top of your schedule? How do you start your day well-rested? metis offers you an effective dose of 'doing' and 'dreaming'. Replenish your nutrition and go full steam ahead.

Benefits and ingredients

We have carefully selected 7 natural ingredients, each with their own specific effect and benefits. metis Anti-Stress 03 has three main benefits:

Supports your body to better deal with stress
The good gut bacteria dampen the stress response
Helps against anxiety and has a calming effect

Lemon balm extract (7% rosemary acid)


Lemon balm is a lemon-scented herb that comes from the same family as mint. The herb is native to Europe, North Africa and Western Asia, but is cultivated throughout the world.


Lemon balm is rich in citronellal and polyphenolic compounds with cholinergic effects. This calms the nervous system and is especially effective for stress, restlessness and irritability.


Supports relaxation

Supports a good night's sleep

Ashwagandha extract (5% withanolides)


The Indian herb Ashwagandha (Withania somnifera), also known as Indian ginseng, has been used for centuries as a beneficial powder for both men and women. In Ayurvedic medicine, this herb is used to treat inflammation and fever, and to protect against infections.


The withanolides, a group of steroidal lactones, have an adrenal supportive effect.


It has a beneficial effect on the heart and blood vessels.

It contributes to balance in stressful situations.

It is beneficial for a good mental balance.

It is calming.

Holy basil extract


Holy basil (also called "Tulsi") is a cognitive enhancer, antioxidant, and adaptogenic herb.


There are a few mechanisms that make holy basil an effective nootropic. One is the flavor profile, which is unique to basil and supports its antioxidant effects. As with many herbs, there are a few key psychoactive ingredients that alter brain chemistry.


Helps reduce inflammation and its symptoms

has a positive effect on stimulating the immune system

also improves responses to stress and anxiety



Magnesium is a mineral vital to the proper functioning of your body and is the second most abundant electrolyte in the human body.


Magnesium supports brain function and has a positive effect on mental endurance. Proper magnesium levels are critical for the electrical potential of nerve cells and for the transmission of impulses in the brain.


Supports brain performance

Supports mental well-being

Improves concentration

Lactobacillus subtilis HU58 & Lactobacillus coagulans


The gut flora has a huge impact on feeling good and mental well-being. Lactobacillus subtilis HU58 is one of the dominant components in a normal intestinal flora. Administering this, boosts immunity and restores intestinal flora.


The formation of feel-good neurotrasmitters are stimulated. Among others, GABA, 5-HTriptophan precursors, peptideyy, SCFAS,. . These will stimulate the sympathetic nervous system and seretonin release. These spore-forming probiotics are acid and heat resistant without losing their unique spore-forming properties.


 Stimulates immunity

Restores intestinal flora

Vitamin B12


Vitamin B12 is an essential nutrient with far-reaching cognitive implications. Almost all of its benefits stem from the role vitamin B12 plays in the process known as "methylation," which affects all aspects of our brains and bodies.


In particular, studies have shown that vitamin B12 helps with neuroprotection by reducing neurotoxicity. For older people, it is even more important for preventing cognitive decline and neurodegenerative diseases. Other benefits include improved memory, concentration and executive function.


Depression prevention and treatment

Promotes brain health

Reduced risk of macular degeneration


1. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy - A Review. Nutrients 2016; 8(2):68.

2. De Ridder K, Bel S, Brocatus L, Cuypers K, Lebacq T, Moyersoen I, Ost C & Teppers E. Food consumption and nutrient intake. In: Bel S, Tafforeau J (ed.). Food consumption survey 2014-2015. Report 4. WIV-ISP, Brussels, 2016.

3. Blumenthal M, Goldberg A, Brinckmann J. Herbal medicine, expanded Commission E Monographs. American Botanical Council 2000; pp170-7.

Discover metis Anti-Stress 03


Effective formulas by Pharmacist Dirk

Metis helps people like you tackle stress-related complaints such as poor sleep, lethargy and hair loss. Our unique formulas are formulated by Pharmacist Dirk, who uses his professional knowledge and personal experience to develop effective formulas. We use only natural, more absorbable substances and use only the best, most concentrated ingredients to ensure a tangible effect. Our formulas are available online and at more than 600 pharmacies and coaches in Belgium and the Netherlands. We are always ready to answer questions and provide personaliZed guidance.

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